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Prostamide F 2 α receptor antagonism combined with inhibition of FAAH may block the pro‐inflammatory mediators formed following selective FAAH inhibition
Author(s) -
Ligresti Alessia,
Martos Jose,
Wang Jenny,
Guida Francesca,
Allarà Marco,
Palmieri Vittoria,
Luongo Livio,
Woodward David,
Di Marzo Vincenzo
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12410
Subject(s) - anandamide , fatty acid amide hydrolase , cannabinoid receptor , endocannabinoid system , cannabinoid , pharmacology , chemistry , receptor , agonist , cannabinoid receptor type 2 , biochemistry , biology
Prostamides are lipid mediators formed by COX-2-catalysed oxidation of the endocannabinoid anandamide and eliciting effects often opposed to those caused by anandamide. Prostamides may be formed when hydrolysis of anandamide by fatty acid amide hydrolase (FAAH) is physiologically, pathologically or pharmacologically decreased. Thus, therapeutic benefits of FAAH inhibitors might be attenuated by concomitant production of prostamide F2 α . This loss of benefit might be minimized by compounds designed to selectively antagonize prostamide receptors and also inhibiting FAAH.