Mitochondrially targeted nitro‐linoleate: a new tool for the study of cardioprotection | Zendy

Nadtochiy Sergiy M | Zendy; Madukwe Jerry | Zendy; Hagen Fred | Zendy; Brookes Paul S | Zendy

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Mitochondrially targeted nitro‐linoleate: a new tool for the study of cardioprotection

Author(s) -

Nadtochiy Sergiy M,

Madukwe Jerry,

Hagen Fred,

Brookes Paul S

Publication year - 2014

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12405

Subject(s) - cardioprotection , mitochondrion , biochemistry , inner mitochondrial membrane , chemistry , viability assay , trypan blue , adenine nucleotide , biology , pharmacology , cell , nucleotide , ischemia , medicine , gene

Cardiac ischaemia-reperfusion (IR) injury remains a significant clinical problem with limited treatment options available. We previously showed that cardioprotection against IR injury by nitro-fatty acids, such as nitro-linoleate (LNO2 ), involves covalent modification of mitochondrial adenine nucleotide translocase 1 (ANT1). Thus, it was hypothesized that conjugation of LNO2 to the mitochondriotropic triphenylphosphonium (TPP(+) ) moiety would enhance its protective properties.

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