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Mitochondrially targeted nitro‐linoleate: a new tool for the study of cardioprotection
Author(s) -
Nadtochiy Sergiy M,
Madukwe Jerry,
Hagen Fred,
Brookes Paul S
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12405
Subject(s) - cardioprotection , mitochondrion , biochemistry , inner mitochondrial membrane , chemistry , viability assay , trypan blue , adenine nucleotide , biology , pharmacology , cell , nucleotide , ischemia , medicine , gene
Cardiac ischaemia-reperfusion (IR) injury remains a significant clinical problem with limited treatment options available. We previously showed that cardioprotection against IR injury by nitro-fatty acids, such as nitro-linoleate (LNO2 ), involves covalent modification of mitochondrial adenine nucleotide translocase 1 (ANT1). Thus, it was hypothesized that conjugation of LNO2 to the mitochondriotropic triphenylphosphonium (TPP(+) ) moiety would enhance its protective properties.