z-logo
Premium
Evolving pharmacology of orphan GPCR s: IUPHAR Commentary
Author(s) -
Davenport Anthony P,
Harmar Anthony J
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12339
Subject(s) - g protein coupled receptor , pharmacology , clinical pharmacology , medicine , biology , receptor
The award of the 2012 N obel P rize in C hemistry to R obert L efkowitz and B rian K obilka for their work on the structure and function of GPCR s, spanning a period of more than 20 years from the cloning of the human β 2 ‐adrenoceptor to determining the crystal structure of the same protein, has earned both researchers a much deserved place in the pantheon of major scientific discoveries. GPCR s comprise one of the largest families of proteins, controlling many major physiological processes and have been a major focus of the I nternational U nion of B asic and C linical P harmacology C ommittee on R eceptor N omenclature and D rug C lassification ( NC ‐ IUPHAR ) since its inception in 1987. We report here recent efforts by the B ritish P harmacological S ociety and NC ‐ IUPHAR to define the endogenous ligands of ‘orphan’ GPCR s and to place authoritative and accessible information about these crucial therapeutic targets online.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here