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Changes in CB 1 and CB 2 receptors in the post‐mortem cerebellum of humans affected by spinocerebellar ataxias
Author(s) -
RodríguezCueto Carmen,
Benito Cristina,
FernándezRuiz Javier,
Romero Julián,
HernándezGálvez Mariluz,
GómezRuiz María
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12283
Subject(s) - cerebellum , cannabinoid receptor , receptor , spinocerebellar ataxia , dentate nucleus , calbindin , endocannabinoid system , biology , endocrinology , neuroscience , medicine , cannabinoid , granular layer , ataxia , agonist , immunohistochemistry
Spinocerebellar ataxias (SCAs) are a family of chronic progressive neurodegenerative diseases, clinically and genetically heterogeneous, characterized by loss of balance and motor coordination due to degeneration of the cerebellum and its afferent and efferent connections. Unlike other motor disorders, the possible role of changes in the endocannabinoid system in the pathogenesis of SCAs has not been investigated.