Antagonism of histamine  H 4   receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis | Zendy

Ballerini C | Zendy; Aldinucci A | Zendy; Luccarini I | Zendy; Galante A | Zendy; Manuelli C | Zendy; Blandina P | Zendy; Katebe M | Zendy; Chazot P L | Zendy; Masini E | Zendy; Passani M B | Zendy

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Antagonism of histamine H 4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis

Author(s) -

Ballerini C,

Aldinucci A,

Luccarini I,

Galante A,

Manuelli C,

Blandina P,

Katebe M,

Chazot P L,

Masini E,

Passani M B

Publication year - 2013

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12263

Subject(s) - myelin oligodendrocyte glycoprotein , experimental autoimmune encephalomyelitis , immunology , foxp3 , biology , receptor , encephalomyelitis , cytokine , inflammation , multiple sclerosis , medicine , endocrinology , immune system

The histamine H4 receptor has a primary role in inflammatory functions, making it an attractive target for the treatment of asthma and refractory inflammation. These observations suggested a facilitating action on autoimmune diseases. Here we have assessed the role of H4 receptors in experimental autoimmune encephalomyelitis (EAE) a model of multiple sclerosis (MS).

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