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Antagonism of histamine H 4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis
Author(s) -
Ballerini C,
Aldinucci A,
Luccarini I,
Galante A,
Manuelli C,
Blandina P,
Katebe M,
Chazot P L,
Masini E,
Passani M B
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12263
Subject(s) - myelin oligodendrocyte glycoprotein , experimental autoimmune encephalomyelitis , immunology , foxp3 , biology , receptor , encephalomyelitis , cytokine , inflammation , multiple sclerosis , medicine , endocrinology , immune system
The histamine H4 receptor has a primary role in inflammatory functions, making it an attractive target for the treatment of asthma and refractory inflammation. These observations suggested a facilitating action on autoimmune diseases. Here we have assessed the role of H4 receptors in experimental autoimmune encephalomyelitis (EAE) a model of multiple sclerosis (MS).