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Potential enhancing effects of histamine H 1 agonism/ H 3 antagonism on working memory assessed by performance and bold response in healthy volunteers
Author(s) -
Ruitenbeek P,
Mehta M A
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12184
Subject(s) - betahistine , psychology , histamine , cognition , neuroscience , working memory , context (archaeology) , schizophrenia (object oriented programming) , antagonist , amisulpride , audiology , medicine , pharmacology , antipsychotic , psychiatry , biology , paleontology , surgery , vertigo , receptor
Schizophrenia is a highly debilitating disorder characterized by hallucinations and delusions, but also impaired cognition such as memory. While hallucinations and delusions are the main target for pharmacological treatment, cognitive impairments are rarely treated. Evidence exists that histamine has a role in the cognitive deficits in schizophrenia, which could be the basis of the development of a histamine-type treatment. Histamine H₃ antagonists have been shown to improve memory performance in experimental animals, but these effects have been little investigated in humans within the context of impaired cognition in schizophrenia and using sensitive measures of brain activity. In the present study, the effects of betahistine (H₃ antagonist/H₁ agonist) on learning and memory, and associated brain activity were assessed.