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Histamine is required for H 3 receptor‐mediated alcohol reward inhibition, but not for alcohol consumption or stimulation
Author(s) -
Vanhanen J,
Nuutinen S,
Lintunen M,
Mäki T,
Rämö J,
Karlstedt K,
Panula P
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12170
Subject(s) - alcohol , stimulation , ethanol , histamine , receptor , chemistry , alcohol consumption , pharmacology , endocrinology , neuroscience , biochemistry , medicine , biology
Conflicting data have been published on whether histamine is inhibitory to the rewarding effects of abused drugs. The purpose of this study was to clarify the role of neuronal histamine and, in particular, H₃ receptors in alcohol dependence-related behaviours, which represent the addictive effects of alcohol.