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Effect of low doses of cannabidiolic acid and ondansetron on LiCl ‐induced conditioned gaping (a model of nausea‐induced behaviour) in rats
Author(s) -
Rock EM,
Parker LA
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12162
Subject(s) - nausea , ondansetron , pharmacology , antagonist , anesthesia , medicine , receptor
Background and Purpose To determine the minimally effective dose of cannabidiolic acid ( CBDA ) that effectively reduces lithium chloride ( LiCl )‐induced conditioned gaping reactions (nausea‐induced behaviour) in rats and to determine if these low systemic doses of CBDA (5–0.1 μg·kg −1 ) relative to those of CBD could potentiate the anti‐nausea effects of the classic 5‐hydroxytryptamine 3 (5‐ HT 3 ) receptor antagonist, ondansetron ( OND ). Experimental Approach We investigated the efficacy of low doses of CBDA to suppress acute nausea, assessed by the establishment of conditioned gaping to a LiCl ‐paired flavour in rats. The potential of threshold and subthreshold doses of CBDA to enhance the reduction of nausea‐induced conditioned gaping by OND were then determined. Key Results CBDA (at doses as low as 0.5 μg·kg −1 ) suppressed nausea‐induced conditioned gaping to a flavour. A low dose of OND (1.0 μg·kg −1 ) alone reduced nausea‐induced conditioned gaping, but when it was combined with a subthreshold dose of CBDA (0.1 μg·kg −1 ) there was an enhancement in the suppression of LiCl ‐induced conditioned gaping. Conclusions and Implications CBDA potently reduced conditioned gaping in rats, even at low doses and enhanced the anti‐nausea effect of a low dose of OND . These findings suggest that combining low doses of CBDA and OND will more effectively treat acute nausea in chemotherapy patients.