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Therapeutic potential of histamine H 4 receptor agonists in triple‐negative human breast cancer experimental model
Author(s) -
Martinel Lamas Diego J,
Croci Maximo,
Carabajal Eliana,
Crescenti Ernesto J V,
Sambuco Lorena,
Massari Noelia A,
Bergoc Rosa M,
Rivera Elena S,
Medina Vanina A
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12137
Subject(s) - histamine , breast cancer , apoptosis , medicine , proliferating cell nuclear antigen , cancer , endocrinology , receptor , mammary gland , histamine h4 receptor , cancer research , immunology , pathology , biology , histamine h2 receptor , immunohistochemistry , antagonist , biochemistry
The presence of the histamine H₄ receptor (H₄R) was previously reported in benign and malignant lesions and cell lines derived from the human mammary gland. The aim of this work was to evaluate the effects of H₄R ligands on the survival, tumour growth rate and metastatic capacity of breast cancer in an experimental model.