Premium
Pharmacological potential of biogenic amine–polyamine interactions beyond neurotransmission
Author(s) -
SánchezJiménez F,
RuizPérez M V,
Urdiales J L,
Medina M A
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12109
Subject(s) - biogenic amine , spermine , putrescine , crosstalk , biochemistry , spermidine , polyamine , receptor , biology , histamine , histidine decarboxylase , signal transduction , intracellular , neurotransmission , ornithine decarboxylase , dopamine , microbiology and biotechnology , chemistry , neuroscience , serotonin , amino acid , pharmacology , enzyme , histidine , physics , optics
Histamine, serotonin and dopamine are biogenic amines involved in intercellular communication with multiple effects on human pathophysiology. They are products of two highly homologous enzymes, histidine decarboxylase and l-aromatic amino acid decarboxylase, and transmit their signals through different receptors and signal transduction mechanisms. Polyamines derived from ornithine (putrescine, spermidine and spermine) are mainly involved in intracellular effects related to cell proliferation and death mechanisms. This review summarizes structural and functional evidence for interactions between components of all these amine metabolic and signalling networks (decarboxylases, transporters, oxidases, receptors etc.) at cellular and tissue levels, distinct from nervous and neuroendocrine systems, where the crosstalk among these amine-related components can also have important pathophysiological consequences. The discussion highlights aspects that could help to predict and discuss the effects of intervention strategies.