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Modulation of neutrophil oxidative burst via histamine receptors
Author(s) -
Číž M,
Lojek A
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12107
Subject(s) - histamine , respiratory burst , histamine h2 receptor , receptor , histamine h4 receptor , histamine receptor , oxidative phosphorylation , histamine h3 receptor , reactive oxygen species , immunology , chemistry , pharmacology , microbiology and biotechnology , biology , biochemistry , agonist , antagonist
Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H1 and H2 receptors in this process is discussed and compared to that of the recently discovered H4 receptor.