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Enhanced anti‐tumour effects of V inca alkaloids given separately from cytostatic therapies
Author(s) -
Ehrhardt H,
Pannert L,
Pfeiffer S,
Wachter F,
Amtmann E,
Jeremias I
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12068
Subject(s) - vinca , in vivo , vinca alkaloid , pharmacology , cell cycle , vincristine , cell , biology , cancer research , medicine , chemotherapy , biochemistry , microbiology and biotechnology , cyclophosphamide
In polychemotherapy protocols, that is for treatment of neuroblastoma and Ewing sarcoma, Vinca alkaloids and cell cycle-arresting drugs are usually administered on the same day. Here we studied whether this combination enables the optimal antitumour effects of Vinca alkaloids to be manifested.