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Characterization of AQX ‐1125, a small‐molecule SHIP1 activator
Author(s) -
Stenton Grant R,
Mackenzie Lloyd F,
Tam Patrick,
Cross Jennifer L,
Harwig Curtis,
Raymond Jeffrey,
Toews Judy,
Wu Joyce,
Ogden Nancy,
MacRury Thomas,
Szabo Csaba
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12039
Subject(s) - cytokine , chemotaxis , activator (genetics) , in vivo , pharmacology , phosphorylation , chemistry , protein kinase b , microbiology and biotechnology , biology , biochemistry , immunology , receptor
The SH2-containing inositol-5'-phosphatase 1 (SHIP1) metabolizes PI(3,4,5)P3 to PI(3,4)P2. SHIP1-deficient mice exhibit progressive inflammation. Pharmacological activation of SHIP1 is emerging as a potential therapy for pulmonary inflammatory diseases. Here we characterize the efficacy of AQX-1125, a small-molecule SHIP1 activator currently in clinical development.