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Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 ( TRPM7 ) channels
Author(s) -
Qin Xin,
Yue Zhichao,
Sun Baonan,
Yang Wenzhong,
Xie Jia,
Ni Eric,
Feng Yi,
Mahmood Rafat,
Zhang Yanhui,
Yue Lixia
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12012
Subject(s) - trpm7 , sphingosine , transient receptor potential channel , lipid signaling , sphingolipid , chemistry , hek 293 cells , biophysics , microbiology and biotechnology , receptor , biology , biochemistry
Transient receptor potential melastatin 7 (TRPM7) is a unique channel kinase which is crucial for various physiological functions. However, the mechanism by which TRPM7 is gated and modulated is not fully understood. To better understand how modulation of TRPM7 may impact biological processes, we investigated if TRPM7 can be regulated by the phospholipids sphingosine (SPH) and sphingosine-1-phosphate (S1P), two potent bioactive sphingolipids that mediate a variety of physiological functions. Moreover, we also tested the effects of the structural analogues of SPH, N,N-dimethyl-D-erythro-sphingosine (DMS), ceramides and FTY720 on TRPM7.