Open AccessZFTA‐YAP1 fusion‐positive ependymoma can occur in the spinal cord: Letter to the editor
Author(s) -
Lim Ka Young,
Lee Kwang Hoon,
Phi Ji Hoon,
Yun Hongseok,
Won Jae Kyung,
Choi Seung Hong,
Park SungHye
Publication year - 2022
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.13020
Subject(s) - ependymoma , spinal cord , medicine , syringomyelia , spinal cord neoplasm , pathology , psychiatry
We report a case of spinal ependymoma with ZFTA‐YAP1 fusion, occurring in a 5‐year‐old boy who complained of back pain. It was high‐grade ependymoma, developed in the spinal cord at the level of T9‐12. Since ZFTA‐YAP1 fusion‐positive ependymoma has never been reported in the spinal cord, this case is exceptional and worth reporting because the anatomical location, genetics, and epigenetics are important parameters in the classification of the ependymal tumor. This is the first case of spinal ependymoma harboring ZFTA ‐fusion to be diagnosed by NGS and Sanger studies to the best of our knowledge.