Open AccessIDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
Author(s) -
Chang Ellen K.,
SmithCohn Matthew A.,
Tamrazi Benita,
Ji Jianling,
Krieger Mark,
Holdhoff Matthias,
Eberhart Charles G.,
Margol Ashley S.,
Cotter Jennifer A.
Publication year - 2021
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12959
Subject(s) - isocitrate dehydrogenase , brainstem , idh1 , young adult , mutant , medicine , glioma , pathology , pediatrics , biology , genetics , cancer research , gene , enzyme , biochemistry
Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH‐mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.