Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits | Zendy

Rademakers Rosa | Zendy; Nicholson Alexandra M. | Zendy; Ren Yingxue | Zendy; Koga Shunsuke | Zendy; Nguyen Hung Phuoc | Zendy; Brooks Mieu | Zendy; Qiao Wenhui | Zendy; Quicksall Zachary S. | Zendy; Matchett Billie | Zendy; Perkerson Ralph B. | Zendy; Kurti Aishe | Zendy; CastanedesCasey Monica | Zendy; Phillips Virginia | Zendy; Librero Ariston L | Zendy; Fernandez De Castro Cristhoper H. | Zendy; Baker Matthew C. | Zendy; Roemer Shanu F. | Zendy; Murray Melissa E. | Zendy; Asmann Yan | Zendy; Fryer John D. | Zendy; Bu Guojun | Zendy; Dickson Dennis W. | Zendy; Zhou Xiaolai | Zendy

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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Author(s) -

Rademakers Rosa,

Nicholson Alexandra M.,

Ren Yingxue,

Koga Shunsuke,

Nguyen Hung Phuoc,

Brooks Mieu,

Qiao Wenhui,

Quicksall Zachary S.,

Matchett Billie,

Perkerson Ralph B.,

Kurti Aishe,

CastanedesCasey Monica,

Phillips Virginia,

Librero Ariston L,

Fernandez De Castro Cristhoper H.,

Baker Matthew C.,

Roemer Shanu F.,

Murray Melissa E.,

Asmann Yan,

Fryer John D.,

Bu Guojun,

Dickson Dennis W.,

Zhou Xiaolai

Publication year - 2021

Publication title -

brain pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.986

H-Index - 132

eISSN - 1750-3639

pISSN - 1015-6305

DOI - 10.1111/bpa.12945

Subject(s) - purkinje cell , cerebellum , neuroscience , motor function , programmed cell death , biology , medicine , physical medicine and rehabilitation , apoptosis , genetics

TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.

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