Open AccessA brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
Author(s) -
Barrington Jack,
Lemarchand Eloise,
Allan Stuart M.
Publication year - 2017
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12476
Subject(s) - pyroptosis , inflammasome , inflammation , stroke (engine) , medicine , mediator , neuroscience , caspase 1 , cytokine , cause of death , programmed cell death , interleukin , immunology , pathology , biology , apoptosis , mechanical engineering , biochemistry , disease , engineering
Stroke is one of the leading causes of death and disability worldwide. Inflammation plays a key role across the time course of stroke, from onset to the post‐injury reparative phase days to months later. Several regulatory molecules are implicated in inflammation, but the most established inflammatory mediator of acute brain injury is the cytokine interleukin‐1. Interleukin‐1 is regulated by large, macromolecular complexes called inflammasomes, which play a central role in cytokine release and cell death. In this review we highlight recent advances in inflammasome research and propose key roles for inflammasome components in the progression of stroke damage.