Open AccessExperimental Spinal Stenosis in Cats: New Insight in Mechanisms of Hydrocephalus Development
Author(s) -
Klarica Marijan,
Jukić Tomislav,
Miše Branko,
Kudelić Nenad,
Radoš Milan,
Orešković Darko
Publication year - 2016
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12337
Subject(s) - cerebrospinal fluid , hydrocephalus , medicine , stenosis , subarachnoid space , fourth ventricle , spinal cord , ventricular system , cerebrospinal fluid pressure , intracranial pressure , ventricle , cerebral ventricle , lateral ventricles , cardiology , anesthesia , anatomy , radiology , psychiatry
In our new experimental model of cervical stenosis without inflammation we have tested hypothesis that cranio‐spinal communication impairment could lead to hydrocephalus development. Spinal and cranial cerebrospinal fluid (CSF) space separation was obtained with positioning of plastic semiring in epidural space at C2 level in cats. Brain ventricles planimetry, and CSF pressure recording in lateral ventricle (LV) and lumbar subarachnoid space (LSS) were performed in acute and subchronic experiments. In all experiments opening CSF pressures were normal. However, in acute experiments, an infusion of artificial CSF into the LV led to increase of CSF pressure and significant gradient pressure development between LV and LSS due to limited pressure transmission. After 3 or 6 weeks spinal cord atrophy was observed at the site of cervical stenosis, and pressure transmission from LV to LSS was improved as a consequence of spinal tissue atrophy. Planimetry of both the coronal brain slices and the ventricles’ surface showed that control ventricular surface was 0.6 ± 0.1% ( n = 5), and 1.6 ± 0.2% ( n = 4) in animals with subchronic cervical stenosis ( P < 0.002). These results support the mentioned hypothesis claiming that CSF volume cranio‐spinal displacement impairment could start pathophysiological processes leading to development of hydrocephalus.