Open AccessUnderstanding Aspects of Aluminum Exposure in A lzheimer's Disease Development
Author(s) -
Kandimalla Ramesh,
Vallamkondu Jayalakshmi,
Corgiat Edwin B,
Gill Kiran Dip
Publication year - 2016
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12333
Subject(s) - neurotoxicity , amyotrophic lateral sclerosis , in vivo , pathogenesis , apoptosis , in vitro , disease , unfolded protein response , microbiology and biotechnology , encephalopathy , medicine , endoplasmic reticulum , chemistry , biology , neuroscience , toxicity , pathology , biochemistry , genetics
Aluminum is a ubiquitously abundant nonessential element. Aluminum has been associated with neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and dialysis encephalopathy. Many continue to regard aluminum as controversial although increasing evidence supports the implications of aluminum in the pathogenesis of AD. Aluminum causes the accumulation of tau protein and Aβ protein in the brain of experimental animals. Aluminum induces neuronal apoptosis in vivo and in vitro , either by endoplasmic stress from the unfolded protein response, by mitochondrial dysfunction, or a combination of them. Some, people who are exposed chronically to aluminum, either from through water and/or food, have not shown any AD pathology, apparently because their gastrointestinal barrier is more effective. This article is written keeping in mind mechanisms of action of aluminum neurotoxicity with respect to AD.