Open AccessmTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment
Author(s) -
Masui Kenta,
Cavenee Webster K.,
Mischel Paul S.
Publication year - 2015
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12307
Subject(s) - reprogramming , biology , effector , cancer cell , cancer research , cancer , mtorc2 , microbiology and biotechnology , genetics , pi3k/akt/mtor pathway , neuroscience , signal transduction , cell , mtorc1
Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Understanding how oncogenes coordinate altered signaling with metabolic reprogramming and how cancer cells harness cellular metabolism and its metabolites for their survival may yield new insights into tumor pathogenesis. Here, we review the recently identified central regulatory role for mTORC2 , a downstream effector of many cancer‐causing mutations, in metabolic reprogramming and cancer drug resistance in glioblastoma. We further consider the emerging concept that mTORC2 may connect genetics with environmental alterations in brain cancer.