Open AccessGenetic Profiling by Single‐Nucleotide Polymorphism‐Based Array Analysis Defines Three Distinct Subtypes of Orbital Meningioma
Author(s) -
Ho ChengYing,
Mosier Stacy,
Safneck Janice,
Salomao Diva R.,
Miller Neil R.,
Eberhart Charles G.,
Gocke Christopher D.,
Batista Denise A. S.,
Rodriguez Fausto J.
Publication year - 2015
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12150
Subject(s) - monosomy , meningioma , biology , chromosome 22 , chromosome , single nucleotide polymorphism , pathology , snp array , karyotype , medicine , genetics , gene , genotype
Orbital meningiomas can be classified as primary optic nerve sheath ( ON ) meningiomas, primary intraorbital ectopic ( O b) meningiomas and spheno‐orbital ( Sph‐O b) meningiomas based on anatomic site. Single‐nucleotide polymorphism ( SNP )‐based array analysis with the I llumina 300 K platform was performed on formalin‐fixed, paraffin‐embedded tissue from 19 orbital meningiomas (5 ON , 4 O b and 10 Sph‐O b meningiomas). Tumors were W orld H ealth O rganization ( WHO ) grade I except for two grade II meningiomas, and one was NF 2‐associated. We found genomic alterations in 68% (13 of 19) of orbital meningiomas. Sph‐O b tumors frequently exhibited monosomy 22/22q loss (70%; 7/10) and deletion of chromosome 1p, 6q and 19p (50% each; 5/10). Among genetic alterations, loss of chromosome 1p and 6q were more frequent in clinically progressive tumors. Chromosome 22q loss also was detected in the majority of O b meningiomas (75%; 3/4) but was infrequent in ON meningiomas (20%; 1/5). In general, O b tumors had fewer chromosome alterations than S ph‐ O b and ON tumors. Unlike Sph‐O b meningiomas, most of the O b and ON meningiomas did not progress even after incomplete excision, although follow‐up was limited in some cases. Our study suggests that ON , O b and Sph‐O b meningiomas are three molecularly distinct entities. Our results also suggest that molecular subclassification may have prognostic implications.