Open Accessα‐Synuclein: The Long Distance Runner
Author(s) -
George Sonia,
Rey Nolwen L.,
Reichenbach Nicole,
Steiner Jennifer A.,
Brundin Patrik
Publication year - 2013
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/bpa.12046
Subject(s) - parkinson's disease , alpha synuclein , neuroscience , disease , lewy body , pathology , dementia with lewy bodies , neurite , medicine , biology , dementia , biochemistry , in vitro
P arkinson's disease is characterized by α‐synuclein pathology in the form of L ewy bodies and L ewy neurites. B raak et al described the spatial and temporal spread of α‐synuclein pathology in P arkinson's disease. Recent experimental studies have demonstrated that α‐synuclein can transfer from cell to cell. In this review, we highlight the involvement of α‐synuclein in P arkinson's disease and in B raak's staging of P arkinson's disease pathology. We discuss whether a prion‐like mechanism of α‐synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell‐to‐cell transfer of α‐synuclein and focus our review on the long‐distance axonal transport of α‐synuclein along neurons.