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Remodelling of membrane tubules by the actin cytoskeleton
Author(s) -
Allard Antoine,
Lopes dos Santos Rogério,
Campillo Clément
Publication year - 2021
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.202000148
Subject(s) - biology , microbiology and biotechnology , actin , cytoskeleton , tubule , organelle , actin cytoskeleton , actin remodeling , membrane , actin remodeling of neurons , biophysics , cell , biochemistry , endocrinology , kidney
Inside living cells, the remodelling of membrane tubules by actomyosin networks is crucial for processes such as intracellular trafficking or organelle reshaping. In this review, we first present various in vivo situations in which actin affects membrane tubule remodelling, then we recall some results on force production by actin dynamics and on membrane tubules physics. Finally, we show that our knowledge of the underlying mechanisms by which actomyosin dynamics affect tubule morphology has recently been moved forward. This is thanks to in vitro experiments that mimic cellular membranes and actin dynamics and allow deciphering the physics of tubule remodelling in biochemically controlled conditions, and shed new light on tubule shape regulation.