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Theileria secretes proteins to subvert its host leukocyte
Author(s) -
Tajeri Shahin,
Langsley Gordon
Publication year - 2021
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.202000096
Subject(s) - biology , theileria , apicomplexa , babesia , virology , intracellular , protozoa , intracellular parasite , host (biology) , microbiology and biotechnology , cryptosporidium parvum , parasite hosting , genetics , immunology , malaria , protozoal disease , world wide web , computer science
Abstract Theileria parasites are classified in the phylum Apicomplexa that includes several genera of medical and veterinary importance such as Plasmodium , Babesia , Toxoplasma and Cryptosporidium . These protozoans have evolved subtle ways to reshape their intracellular niche for their own benefit and Theileria is no exception. This tick transmitted microorganism is unique among all eukaryotes in that its intracellular schizont stage is able to transform its mammalian host leukocytes into an immortalised highly disseminating cell that phenocopies tumour cells. Here, we describe what is known about secreted Theileria‐ encoded host cell manipulators.