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Motile ciliogenesis and the mitotic prism
Author(s) -
Al Jord Adel,
Spassky Nathalie,
Meunier Alice
Publication year - 2019
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.201800072
Subject(s) - ciliogenesis , cilium , motile cilium , biology , microbiology and biotechnology , mitosis , ciliopathy , organelle , intraflagellar transport , cellular differentiation , genetics , phenotype , flagellum , gene
Motile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis. Defects in multiciliated cell differentiation lead to severe cilia‐related diseases by perturbing cilia‐based flows. Recent work designated the machinery of mitosis as the orchestrator of the orderly progression of differentiation associated with multiple motile cilia formation. By examining the events leading to motile ciliogenesis with a methodological prism of mitosis, we contextualise and discuss the recent findings to broaden the spectrum of questions related to the differentiation of mammalian multiciliated cells.