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Modulation of chromatin function through linker histone H1 variants
Author(s) -
Kowalski Andrzej,
Pałyga Jan
Publication year - 2016
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.201600007
Subject(s) - chromatin , biology , histone h1 , histone , linker , histone code , nucleosome , microbiology and biotechnology , chromatin remodeling , genetics , function (biology) , histone modifying enzymes , computational biology , gene , computer science , operating system
In this review, the structural aspects of linker H1 histones are presented as a background for characterization of the factors influencing their function in animal and human chromatin. The action of H1 histone variants is largely determined by dynamic alterations of their intrinsically disordered tail domains, posttranslational modifications and allelic diversification. The interdependent effects of these factors can establish dynamic histone H1 states that may affect the organization and function of chromatin regions.