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Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I‐BAR proteins
Author(s) -
Lemichez Emmanuel,
GonzalezRodriguez David,
Bassereau Patricia,
BrochardWyart Françoise
Publication year - 2013
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.201200063
Subject(s) - dewetting , nucleation , membrane curvature , cytoskeleton , biophysics , contractility , actin , transcellular , biology , tension (geology) , surface tension , membrane , microbiology and biotechnology , nanotechnology , materials science , cell , chemistry , biochemistry , physics , composite material , thin film , vesicle , organic chemistry , quantum mechanics , endocrinology , ultimate tensile strength
Dewetting is the spontaneous withdrawal of a liquid film from a non‐wettable surface by nucleation and growth of dry patches. Two recent reports now propose that the principles of dewetting explain the physical phenomena underpinning the opening of transendothelial cell macroaperture (TEM) tunnels, referred to as cellular dewetting. This was discovered by studying a group of bacterial toxins endowed with the property of corrupting actomyosin cytoskeleton contractility. For both liquid and cellular dewetting, the growth of holes is governed by a competition between surface forces and line tension. We also discuss how the dynamics of TEM opening and closure represent remarkable systems to investigate actin cytoskeleton regulation by sensors of plasma membrane curvature and investigate the impact on membrane tension and the role of TEM in vascular dysfunctions.