Premium
Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin‐related modifiers
Author(s) -
Wang Yao E.,
Pernet Olivier,
Lee Benhur
Publication year - 2012
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/boc.201100105
Subject(s) - sumo protein , ubiquitin , microbiology and biotechnology , biology , nuclear transport , deubiquitinating enzyme , sumo enzymes , ubiquitins , f box protein , nuclear protein , function (biology) , ubiquitin ligase , cell nucleus , nucleus , biochemistry , transcription factor , gene
Abstract Nucleocytoplasmic trafficking of many cellular proteins is regulated by nuclear import/export signals as well as post‐translational modifications such as covalent conjugation of ubiquitin and small ubiquitin‐related modifiers (SUMOs). Ubiquitination and SUMOylation are rapid and reversible ways to modulate the intracellular localisation and function of substrate proteins. These pathways have been co‐opted by some viruses, which depend on the host cell machinery to transport their proteins in and out of the nucleus. In this review, we will summarise our current knowledge on the ubiquitin/SUMO‐regulated nuclear/subnuclear trafficking of cellular proteins and describe examples of viral exploitation of these pathways.