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A note on statistical power in multi‐site randomized trials with multiple treatments at each site
Author(s) -
Liu Xiaofeng Steven
Publication year - 2014
Publication title -
british journal of mathematical and statistical psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.157
H-Index - 51
eISSN - 2044-8317
pISSN - 0007-1102
DOI - 10.1111/bmsp.12016
Subject(s) - statistic , statistics , wald test , mathematics , test statistic , statistical hypothesis testing , contrast (vision) , statistical power , variance (accounting) , econometrics , computer science , artificial intelligence , accounting , business
We derive the statistical power functions in multi‐site randomized trials with multiple treatments at each site, using multi‐level modelling. An F statistic is used to test multiple parameters in the multi‐level model instead of the Wald chi square test as suggested in the current literature. The F statistic is shown to be more conservative than the Wald statistic in testing any overall treatment effect among the multiple study conditions. In addition, we improvise an easy way to estimate the non‐centrality parameters for the means comparison t ‐tests and the F test, using Helmert contrast coding in the multi‐level model. The variance of treatment means, which is difficult to fathom but necessary for power analysis, is decomposed into intuitive simple effect sizes in the contrast tests. The method is exemplified by a multi‐site evaluation study of the behavioural interventions for cannabis dependence.