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Challenges, applications and future directions of precision medicine in prostate cancer – the role of organoids and patient‐derived xenografts
Author(s) -
Joshi Andre,
Roberts Matthew J.,
Alinezhad Saeid,
Williams Elizabeth D.,
Vela Ian
Publication year - 2020
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.15103
Subject(s) - medicine , precision medicine , prostate cancer , narrative review , cancer , personalized medicine , medical physics , clinical practice , intensive care medicine , cancer medicine , prostate , bioinformatics , pathology , family medicine , biology
Objective To provide a clinically relevant outline of various current precision medicine principles and available evidence on the application and potential for a precision medicine approach in prostate cancer. Methods Narrative review of the current literature in the field. Conclusion Precision medicine is the concept of individualising patient management based on specific tumour characteristics and biology, rather than traditional histological subtypes. The overall aim is to personalise management to individual patients, to provide the right cancer treatment, to the right patient, at the right time. While the approach aims to improve clinical outcomes, decrease morbidity and improve survival in men with advanced prostate cancer, its clinical application is in its infancy. It does however show great promise in this and other cancers, and will continue to be an area of active research and clinical investigation.