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Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan
Author(s) -
Matsumoto Teppei,
Hatakeyama Shingo,
Imai Atsushi,
Tanaka Toshikazu,
Hagiwara Kazuhisa,
Konishi Sakae,
Okita Kazutaka,
Yamamoto Hayato,
Tobisawa Yuki,
Yoneyama Tohru,
Yoneyama Takahiro,
Hashimoto Yasuhiro,
Koie Takuya,
Nakaji Shigeyuki,
Ohyama Chikara
Publication year - 2019
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.14535
Subject(s) - nocturia , medicine , lower urinary tract symptoms , international prostate symptom score , overactive bladder , logistic regression , oxidative stress , population , urinary system , urology , prostate , environmental health , pathology , alternative medicine , cancer
Objective To investigate the relationship between oxidative stress and lower urinary tract symptoms (LUTS) in a community‐dwelling population. Materials and Methods The cross‐sectional study included 1 113 people who participated in the Iwaki Health Promotion Project of 2015 in Hirosaki, Japan. LUTS were assessed using structured questionnaires, including the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS). IPSS > 7, OABSS > 5, nocturia score > 1, or urge incontinence score > 1 were defined as moderate to severe symptoms. 8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG) and advanced glycation end products (AGEs) were measured by urine analysis and skin autofluorescence, respectively. The relationship between oxidative stress and LUTS was investigated using logistic regression analyses. Results This study included 431 men and 682 women. AGEs and 8‐OHdG levels were significantly higher in severe forms of LUTS. Multivariate logistic regression analyses showed that AGE levels were significantly associated with a higher frequency of nocturia but were not associated with IPSS, OABSS or urge incontinence. No significant association was observed between LUTS and 8‐OHdG levels. Conclusions We observed a significant association between AGE levels and nocturia score > 1. Further research is necessary to clarify a possible causal relationship between oxidative stress and nocturia.