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Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta‐analysis
Author(s) -
Gandhi Niket,
Krishna Satheesh,
Booth Christopher M.,
Breau Rodney H.,
Flood Trevor A.,
Morgan Scott C.,
Schieda Nicola,
Salameh JeanPaul,
McGrath Trevor A.,
McInnes Matthew D.F.
Publication year - 2018
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.14366
Subject(s) - medicine , meta analysis , magnetic resonance imaging , confidence interval , stage (stratigraphy) , bladder cancer , diagnostic accuracy , gold standard (test) , radiology , nuclear medicine , cancer , paleontology , biology
The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T‐stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of patients with bladder cancer undergoing T‐staging MRI to evaluate the diagnostic accuracy using bivariate random‐effects meta‐analysis. Sub‐group analysis was done to explore variability; risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)‐2 tool. The search identified 30 studies (5156 patients). Pooled accuracy at multiple T‐stage thresholds: ≤T1 vs ≥T2 = sensitivity 87% (95% confidence interval [CI] 82–91), specificity 79% (95% CI 72–85); T‐any vs T0 = sensitivity 65% (95% CI 23–92), specificity 90% (95% CI 83–94); ≤T2 vs ≥T3 = sensitivity 83% (95% CI 75–88), specificity 87% (95% CI 78–93); and