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Real‐world uptake, safety profile and outcomes of docetaxel in newly diagnosed metastatic prostate cancer
Author(s) -
Rulach Robert J.,
McKay Stephen,
Neilson Sam,
White Lillian,
Wallace Jan,
Carruthers Ross,
Lamb Carolynn,
Cascales Almudena,
Marashi Husam,
Glen Hilary,
Venugopal Balaji,
Sadoyze Azmat,
Sidek Norma,
Russell J. Martin,
Alhasso Abdulla,
Dodds David,
Laskey Jennifer,
Jones Robert J.,
MacLeod Nicholas
Publication year - 2018
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.14025
Subject(s) - docetaxel , medicine , febrile neutropenia , prostate cancer , neutropenia , hazard ratio , chemotherapy , oncology , androgen deprivation therapy , cancer , confidence interval
Objectives To investigate the uptake, safety and efficacy of docetaxel chemotherapy in hormone‐naïve metastatic prostate cancer (mPC) in the first year of use outside of a clinical trial. Patients and Methods Patients in the West of Scotland Cancer Network with newly diagnosed mPC were identified from the regional multidisciplinary team meetings and their treatment details were collected from electronic patient records. The rate of febrile neutropenia, hospitalisations, time to progression, and overall survival were compared between those patients who received docetaxel and androgen‐deprivation therapy (ADT), or ADT alone using survival analysis. Results Of the 270 eligible patients, 103 received docetaxel (38.1%). 35 patients (34%) were hospitalised and there were 17 episodes of febrile neutropenia (16.5%). Two patients (1.9%) died within 30 days of chemotherapy. Patients who received ADT alone had an increased risk of progression (hazard ratio [HR] 2.03, 95% confidence interval [CI] 1.27–3.25; log‐rank test, P = 0.002) and had an increased risk of death (HR 5.88, 95% CI: 2.52–13.72; log‐rank test, P = 0.001) compared to the docetaxel group. The risk of febrile neutropenia was nine‐times greater if chemotherapy was started within 3 weeks of ADT initiation (95% CI: 1.22–77.72; P = 0.032). Conclusion Docetaxel chemotherapy in hormone‐naïve mPC has significant toxicities, but has a similar effect on time to progression and overall survival as seen in randomised trials. Chemotherapy should be started at ≥3 weeks after ADT.