z-logo
Premium
Time on androgen deprivation therapy and adaptations to exercise: secondary analysis from a 12‐month randomized controlled trial in men with prostate cancer
Author(s) -
Taaffe Dennis R.,
Buffart Laurien M.,
Newton Robert U.,
Spry Nigel,
Denham James,
Joseph David,
Lamb David,
Chambers Suzanne K.,
Galvão Daniel A.
Publication year - 2018
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.14008
Subject(s) - androgen deprivation therapy , lean body mass , medicine , prostate cancer , randomized controlled trial , confidence interval , testosterone (patch) , physical therapy , cancer , body weight
Objectives To explore if duration of previous exposure to androgen deprivation therapy ( ADT ) in men with prostate cancer ( PC a) undertaking a year‐long exercise programme moderates the exercise response with regard to body composition and muscle performance, and also to explore the moderator effects of baseline testosterone, time since ADT , and baseline value of the outcome. Patients and Methods In a multicentre randomized controlled trial, 100 men who had previously undergone either 6 months (short‐term) or 18 months (long‐term) of ADT in combination with radiotherapy, as part of the TROG 03.04 RADAR trial, were randomized to 6 months supervised exercise, followed by a 6‐month home‐based maintenance programme, or to printed physical activity educational material for 12 months across 13 university‐affiliated exercise clinics in Australia and New Zealand. The participants were long‐term survivors of PC a with a mean age of 71.7 ± 6.4 years, and were assessed for lower extremity performance (repeated chair rise), with a subset of men ( n = 57) undergoing additional measures for upper and lower body muscle strength and body composition (lean mass, fat mass, appendicular skeletal muscle [ ASM ]) by dual X‐ray absorptiometry. Data were analysed using generalized estimating equations. Results Time on ADT significantly moderated the exercise effects on chair rise (β interaction = −1.3 s, 95% confidence interval [ CI ] −2.6 to 0.0), whole‐body lean mass (β interaction = 1194 g, 95% CI 234 to 2153) and ASM mass (β interaction = 562 g, 95% CI 49 to 1075), and approached significance for fat mass (β interaction = −1107 g, 95% CI −2346 to 132), with greater benefits for men previously on long‐term ADT . At 6 months, the intervention effects on chair rise time −1.5 s (95% CI −2.5 to −0.5), whole‐body lean mass 824 g (95% CI 8 to 1640), ASM mass 709 g (95% CI 260 to 1158), and fat mass −1377 g (95% CI −2156 to −598) were significant for men previously on long‐term ADT , but not for men on short‐term ADT . At 12 months, the intervention effects for men on long‐term ADT remained significant for the chair rise, with improved performance (−2.0 s, 95% CI −3.0 to −1.0) and increased ASM (537 g, 95% CI 153 to 921). Time on ADT did not moderate the exercise effects on muscle strength, nor did time since ADT cessation moderate any intervention effects. Similarly, testosterone and baseline values of the outcome had negligible moderator effects. Conclusions Men with PC a previously treated long‐term with ADT respond more favourably to exercise in terms of lower body muscle performance and body composition (lean and fat mass, and ASM ) than those with short‐term ADT exposure. As a result, men who were formerly on long‐term androgen suppression regimens should be especially prescribed exercise medicine interventions to alleviate residual treatment‐related adverse effects.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here