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A multiparametric magnetic resonance imaging‐based risk model to determine the risk of significant prostate cancer prior to biopsy
Author(s) -
Leeuwen Pim J.,
Hayen Andrew,
Thompson James E.,
Moses Daniel,
Shnier Ron,
Böhm Maret,
Abuodha Magdaline,
Haynes AnneMaree,
Ting Francis,
Barentsz Jelle,
Roobol Monique,
Vass Justin,
Rasiah Krishan,
Delprado Warick,
Stricker Phillip D.
Publication year - 2017
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.13814
Subject(s) - prostate cancer , medicine , prostate , magnetic resonance imaging , rectal examination , biopsy , concordance , prostate biopsy , logistic regression , radiology , prostate specific antigen , cancer
Objective To develop and externally validate a predictive model for detection of significant prostate cancer. Patients and Methods Development of the model was based on a prospective cohort including 393 men who underwent multiparametric magnetic resonance imaging (mp MRI ) before biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent mp MRI followed by biopsy for abnormal prostate‐specific antigen ( PSA ) level or digital rectal examination ( DRE ). A model was developed with age, PSA level, DRE , prostate volume, previous biopsy, and Prostate Imaging Reporting and Data System ( PIRADS ) score, as predictors for significant prostate cancer (Gleason 7 with >5% grade 4, ≥20% cores positive or ≥7 mm of cancer in any core). Probability was studied via logistic regression. Discriminatory performance was quantified by concordance statistics and internally validated with bootstrap resampling. Results In all, 393 men had complete data and 149 (37.9%) had significant prostate cancer. While the variable model had good accuracy in predicting significant prostate cancer, area under the curve ( AUC ) of 0.80, the advanced model (incorporating mp MRI ) had a significantly higher AUC of 0.88 ( P < 0.001). The model was well calibrated in internal and external validation. Decision analysis showed that use of the advanced model in practice would improve biopsy outcome predictions. Clinical application of the model would reduce 28% of biopsies, whilst missing 2.6% significant prostate cancer. Conclusions Individualised risk assessment of significant prostate cancer using a predictive model that incorporates mp MRI PIRADS score and clinical data allows a considerable reduction in unnecessary biopsies and reduction of the risk of over‐detection of insignificant prostate cancer at the cost of a very small increase in the number of significant cancers missed.