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Association between number of prostate biopsies and patient‐reported functional outcomes after radical prostatectomy: implications for active surveillance protocols
Author(s) -
Anderson Christopher B.,
Tin Amy L.,
Sjoberg Daniel D.,
Mulhall John P.,
Sandhu Jaspreet,
Touijer Karim,
Laudone Vincent P.,
Eastham James A.,
Scardino Peter T.,
Ehdaie Behfar
Publication year - 2016
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.13215
Subject(s) - medicine , prostatectomy , urology , prostate cancer , erectile dysfunction , odds ratio , confidence interval , prostate , prostate biopsy , urinary continence , logistic regression , biopsy , erectile function , urinary incontinence , cancer
Objectives To evaluate whether the number of preoperative prostate biopsies affects functional outcomes after radical prostatectomy ( RP ). Methods We identified patients treated with RP at our institution between 2008 and 2011. At 6 and 12 months postoperatively, the patients completed questionnaires assessing erectile and urinary function. Patients with preoperative incontinence or erectile dysfunction or who did not complete the questionnaire were excluded. Primary outcomes were urinary and erectile function at 12 months postoperatively. We used logistic regression to estimate the impact of number of prostate biopsies on functional outcomes after adjusting for demographic and clinical factors. Results We identified 2 712 patients treated with RP between 2008 and 2011. Most of the patients (80%) had one preoperative prostate biopsy, 16% had two, and 4% had at least three. On adjusted analysis, erectile function at 12 months was not significantly different for patients with two (odds ratio [ OR ] 1.25; 95% confidence interval [ CI ] 0.90, 1.75) or three or more ( OR 1.52; 95% CI 0.84, 2.78) biopsies, compared with those with one biopsy. Similarly, urinary function at 12 months was not significantly different for patients with two (0.84, 95% CI 0.64, 1.10) or three or more (0.99, 95% CI 0.60, 1.61) biopsies compared with those with one. Conclusions We did not find evidence that a greater number of preoperative prostate biopsies adversely affected erectile or urinary function at 12 months after RP .