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Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high‐risk non‐muscle‐invasive bladder cancer treated with maintenance intravesical Bacillus Calmette‐Guérin
Author(s) -
Baltacı Sümer,
Bozlu Murat,
Yıldırım Asıf,
Gökçe Mehmet İlker,
Tinay İlker,
Aslan Güven,
Can Cavit,
Türkeri Levent,
Kuyumcuoğlu Uğur,
Mungan Aydın
Publication year - 2015
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.13102
Subject(s) - medicine , bladder cancer , confidence interval , odds ratio , urology , logistic regression , cystectomy , surgery , multivariate analysis , tumor progression , cancer
Objectives To evaluate the effect of the interval between the initial and second transurethral resection ( TUR ) on the outcome of patients with high‐risk non‐muscle‐invasive bladder cancer ( NMIBC ) treated with maintenance intravesical Bacillus Calmette‐Guérin ( BCG ) therapy. Patients and Methods We reviewed the data of patients from 10 centres treated for high‐risk NMIBC between 2005 and 2012. Patients without a diagnosis of muscle‐invasive cancer on second TUR performed ≤90 days after a complete first TUR , and received at least 1 year of maintenance BCG were included in this study. The interval between first and second TUR in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression. Results In all, 242 patients were included. The mean ( sd , range) follow‐up was 29.4 (22.2, 12–96) months. The 3‐year recurrence‐ and progression‐free survival rates of patients who underwent second TUR between 14 and 42 days and 43–90 days were 73.6% vs 46.2% ( P < 0.001) and 89.1% vs 79.1% ( P = 0.006), respectively. On multivariate analysis, the interval to second TUR was found to be a predictor of both recurrence [odds ratio ( OR ) 3.598, 95% confidence interval ( CI ) 1.885–8.137; P = 0.001] and progression ( OR 2.144, 95% CI 1.447–5.137; P = 0.003). Conclusions The interval between first and second TUR should be ≤42 days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second TUR on patient outcomes.