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Telemetric monitoring of bladder function in female Göttingen minipigs
Author(s) -
Huppertz Nadine D.,
KirschnerHermanns Ruth,
Tolba Rene H.,
Grosse Joachim O.
Publication year - 2015
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.13089
Subject(s) - cystometry , medicine , urology , urination , bladder outlet obstruction , overactive bladder , urinary bladder , urinary system , prostate , pathology , alternative medicine , cancer
Objectives To generate real‐time radio‐telemetric urodynamic reference data of maximum detrusor pressure ( P det max ), maximum flow rate ( Q max) and estimated grade of infravesical obstruction, as well as duration of detrusor contraction ( DOC ), in female Göttingen minipigs and to describe translational aspects of the use of Göttingen minipigs for urological research. Materials and Methods A telemetric transmitter was implanted into five female Göttingen minipigs, and 24 h measurements in metabolic cages were taken. Through operator‐based analysis, synchronized real‐time radio‐telemetric cystometric data with flowmetric data and video sequences were used to determine voiding detrusor contractions ( VC s) and non‐voiding detrusor contractions ( NVC s). Furthermore, data from telemetric natural‐filling cystometry from free‐moving and restricted maintenance conditions were compared for potential differences. Results The median (range) P det max of VC s was 120.6 (21.0–370.0) cmH 2 O and, therefore, significantly different from that of NVC s (64.60 [20.4–280.6 cmH 2 O] cm H 2 O). Intraindividual comparison of minipig data revealed great differences in voiding contractions. The effects of limited movement on VC s were analysed and showed significantly higher P det max and lower DOC than in free‐moving conditions. Conclusion The presented data can be used for the development of telecystometric implanted minipig models, to investigate changes of detrusor function such as under‐ or overactivity, and might serve as model for bladder changes occurring with iatrogenic bladder outlet obstruction ( BOO ) or different therapeutic options for overactive bladder. Radio‐telemetric real‐time natural filling and voiding cystometries are feasible, reproducible in non‐anaesthetized minipigs with free or limited movement and can give new insights into circadian behaviour and physiological and pathological bladder function.