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Obesity is associated with higher risk of prostate cancer detection in a biopsy population in K orea
Author(s) -
Park Juhyun,
Cho Sung Yong,
Lee Seung Bae,
Son Hwancheol,
Jeong Hyeon
Publication year - 2014
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12600
Subject(s) - prostate cancer , medicine , prostate biopsy , biopsy , body mass index , rectal examination , obesity , prostate , population , odds ratio , urology , gynecology , cancer , transrectal ultrasonography , prostate specific antigen , environmental health
Objective To evaluate the impact of obesity on prostate cancer detection, as measured by the body mass index ( BMI ) in a K orean biopsy population. Patients and Methods We retrospectively reviewed the records of 1213 men who underwent transrectal ultrasonography‐guided prostate biopsy at our institution. Biopsy outcomes were analysed with respect to various variables, including patient age, prostate‐specific antigen ( PSA ), prostate volume, digital rectal examination ( DRE ) findings and obesity, defined as BMI ≥25 kg/m 2 , an A sian BMI category. Results Among 1213 men, 408 (33.6%) were obese and 344 (28.4%) had a positive biopsy. Obese men were younger (65.5 vs 67.1 years, P = 0.003), had a larger prostate (49.2 vs 42.9 mL, P < 0.001) and were less likely to have any abnormality on DRE (8.1 vs 15.9% P < 0.001) than non‐obese men. In the multivariate analysis, obesity was significantly associated with a higher risk of prostate cancer detection in men undergoing biopsy (odds ratio [ OR ] = 1.446, P = 0.024). In addition, obesity was significantly associated with a higher rate of biopsy‐detected high grade ( G leason score ≥4 + 3) disease, and this association remained after multivariate adjustment ( OR = 1.498, P = 0.039). Conclusions Obese men were younger, had a larger prostate, and had less tendency to have an abnormality on DRE than non‐obese men. Obesity was associated with a higher risk of prostate cancer detection as an independent factor, including high grade prostate cancer in a K orean biopsy population.