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Incremental detection rate of prostate cancer by real‐time elastography targeted biopsies in combination with a conventional 10‐core biopsy in 1024 consecutive patients
Author(s) -
Salomon Georg,
Drews Nils,
Autier Philippe,
Beckmann Ann,
Heinzer Hans,
Hansen Jens,
Michl Uwe,
Schlomm Thorsten,
Haese Alex,
Steuber Thomas,
Graefen Markus,
Becker Andreas
Publication year - 2014
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12517
Subject(s) - medicine , biopsy , prostate cancer , radiology , elastography , prostate biopsy , randomized controlled trial , core biopsy , cancer , ultrasound , breast cancer
Objective To quantify the incremental detection rate ( DR ) of a targeted biopsy in addition to a randomized 10‐core biopsy.Patients and Methods This retrospective study analysed 1024 patients who consecutively underwent a four‐core real‐time elastography ( RTE ) targeted biopsies in addition to a randomized 10‐core transrectal ultrasonography ( TRUS )‐guided biopsy in a primary or rebiopsy setting. The overall DR , the DR of a 10‐core randomized, RTE targeted biopsy and the incremental DR were calculated.Results Overall, randomized and RTE targeted biopsy DRs (for the combination, the 10‐core and the four‐core RTE biopsy scheme) were 46.2% ( n = 473), 39.1% ( n = 400) and 29.0% ( n = 297), respectively. Four‐core RTE targeted biopsies detected an additional 73 patients not detected by the 10‐core randomized biopsies (increase in the overall DR of 7.1%). This represented a relative increase in DR of 18.3%. The incremental DR was better in rebiopsy patients (24.8%) than in patients having their first biopsy (14.7%). Within all patients diagnosed by RTE targeted biopsy only, 34 patients harboured significant Gleason 4 or 5 prostate cancer (PCa), diagnosed by four‐core RTE biopsy only. Moreover, PCa with a Gleason grade of 4 or 5 was detected by four‐core RTE biopsies in 30 patients, who showed low‐grade PCa ≤ Gleason 3 only in the systematic 10‐core biopsy.Conclusions Real‐time elastography targeted biopsy seems to be an appropriate method for increasing the DR of PCa . Nevertheless, RTE targeted biopsies missed a high proportion of patients with PCa and should therefore be considered as an addition to randomized biopsies.