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Evaluation of ABO blood group as a prognostic marker in renal cell carcinoma ( RCC )
Author(s) -
Martino Michela,
Waldert Matthias,
Haitel Andrea,
Schatzl Georg,
Shariat Shahrokh F.,
Klatte Tobias
Publication year - 2014
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12436
Subject(s) - abo blood group system , medicine , renal cell carcinoma , proportional hazards model , lymph node , stage (stratigraphy) , pathological , oncology , gastroenterology , carcinoma , urology , biology , paleontology
Objective To evaluate ABO blood group as a prognostic marker in patients with renal cell carcinoma ( RCC ).Patients and Methods This retrospective study included 556 consecutive patients who underwent surgery for RCC at a single institution. The associations of ABO blood group with clinical and pathological variables were assessed using K ruskal– W allis and chi‐squared tests. The impact on overall survival ( OS ) and RCC ‐specific survival ( RCC‐SS ) was analysed using univariable and multivariable C ox proportional hazards regression models.Results Blood group O was associated with the absence of lymph node metastases (P = 0.034) and the presence of bilateral RCC (P = 0.017). No associations with age, gender, body mass index, C harlson comorbidity index, T stage, M stage, grade and histological subtype were observed. In univariable and multivariable survival analysis, ABO blood group was not associated with OS and RCC‐SS .Conclusions In the present study, ABO blood group was not linked with RCC prognosis. Blood group O may be associated with the absence of lymph node metastases and the presence of bilateral RCC . External validation in larger cohorts is necessary.