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Application of 11 C‐acetate positron‐emission tomography ( PET ) imaging in prostate cancer: systematic review and meta‐analysis of the literature
Author(s) -
Mohsen Beheshti,
Giorgio Treglia,
Rasoul Zakavi Seyed,
Werner Langsteger,
Ali Ghodsi Rad Mohammad,
Reza Dabbagh Kakhki Vahid,
Ramin Sadeghi
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12279
Subject(s) - prostate cancer , positron emission tomography , medicine , meta analysis , nuclear medicine , cancer , prostate , oncology , radiology
To review the literature on the application of 11 C‐acetate positron‐emission tomography ( PET ) imaging in prostate cancer.We systematically reviewed the available literature and presented the results in meta‐analysis format. Pub M ed, SCOPUS , ISI web of knowledge, S cience D irect, S pringer, and G oogle S cholar were searched with ‘ A cetate AND PET AND P rostate’ as keywords. All studies that evaluated accuracy of 11 C‐acetate imaging in primary or recurrent prostate cancer were included, if enough data could be extracted for calculation of sensitivity and/or specificity.In all, 23 studies were included in the study. For evaluation of primary tumour, pooled sensitivity was 75.1 (69.8–79.8)% and specificity was 75.8 (72.4–78.9)%. For detection of recurrence, sensitivity was 64 (59–69)% and specificity was 93 (83–98)%. Sensitivity for recurrence detection was higher in post‐surgical vs post‐radiotherapy patients and in patients with PSA at relapse of >1 ng/mL. Studies using PET /computed tomography vs PET also showed higher sensitivity for detection of recurrence.Imaging with 11 C‐acetate PET can be useful in patients with prostate cancer. This is especially true for evaluation of patients at PSA relapse, although the sensitivity is overall low. For primary tumour evaluation (localisation of tumour in the prostate and differentiation of malignant from benign lesions), 11 C‐acetate is of limited value due to low sensitivity and specificity. Due to the poor quality of the included studies, the results should be interpreted with caution and further high‐quality studies are needed.