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Common prescription medication use and erectile dysfunction: results from the B oston A rea C ommunity H ealth ( BACH ) survey
Author(s) -
Kupelian Varant,
Hall Susan A.,
McKinlay John B.
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12231
Subject(s) - medicine , odds ratio , erectile dysfunction , confounding , medical prescription , confidence interval , logistic regression , tricyclic , adverse effect , pharmacology
Objective To investigate the association of erectile dysfunction ( ED ) with commonly used medications including antihypertensive treatment ( AHT ), psychoactive medication and pain and anti‐inflammatory medication.Subjects and Methods The B oston A rea C ommunity H ealth ( BACH ) survey used a multistage stratified design to recruit a random sample of 2301 men aged 30–79 years. E D was assessed using the five‐item I nternational I ndex of E rectile F unction ( IIEF ‐5). Prescription medications, captured using a combination of drug inventory and self‐report with a prompt by indication, included in this analysis comprised AHT , psychoactive medication, and pain and anti‐inflammatory medication. Logistic regression was used to estimate the odds ratios ( ORs ) of the association of medication use with ED and to adjust for potential confounders including age, comorbid conditions and sociodemographic and lifestyle factors.Results Multivariable analyses showed benzodiazepines (adjusted OR = 2.34, 95% confidence interval [ CI ]: 1.03, 5.31) and tricyclic antidepressants (adjusted OR = 3.35, 95% CI : 1.09, 10.27) were associated with ED , while no association was observed for serotonin reuptake inhibitors/serotonin‐norepinephrine reuptake inhibitors and atypical antipsychotics. The use of AHT , whether in monotherapy or in conjunction with other AHTs , and pain or anti‐inflammatory medications were not associated with ED after accounting for confounding factors.Conclusions Results of the BACH survey suggest adverse effects of some psychoactive medications (benzodiazepines and tricyclic antidepressants). No evidence of an association of AHT or pain and anti‐inflammatory medication with ED was observed.