Premium
Manganese superoxide dismutase Ile58Thr , catalase C ‐262 T and myeloperoxidase G ‐463 A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease
Author(s) -
Tefik Tzevat,
Kucukgergin Canan,
Sanli Oner,
Oktar Tayfun,
Seckin Sule,
Ozsoy Cavit
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12176
Subject(s) - genotype , prostate cancer , myeloperoxidase , gene polymorphism , medicine , biology , gastroenterology , cancer , microbiology and biotechnology , immunology , gene , genetics , inflammation
Objective To evaluate the relationship between manganese superoxide dismutase ( MnSOD ) Ile58Thr , catalase ( CAT ) C ‐262 T and myeloperoxidase ( MPO ) G ‐463 A gene polymorphisms and the susceptibility and clinicopathological characteristics of prostate cancer.Patients and Methods In all, 155 patients diagnosed with prostate cancer and 195 controls with negative digital rectal examinations and PSA levels of <4 ng/dL were enrolled in this study. MnSOD , CAT and MPO gene polymorphisms were identified by polymerase chain reaction restriction‐fragment length polymorphism methods.Results The TT genotype in MnSOD Ile58Thr polymorphism, CC genotype in the CAT C ‐262 T polymorphism and the GG genotype in the MPO G ‐463 A polymorphism were the predominant genotypes amongst this T urkish male population. There was no association between MnSOD Ile58Thr polymorphism and prostate cancer. For the CAT C ‐262 T polymorphism, the TT genotype had significantly increased prostate cancer risk compared with the CC genotype. Similarly, the TT genotype had a 1.94‐ and 3.83‐fold increased risk for high‐stage disease and metastasis, respectively, when compared with the CC genotype. For the MPO G ‐463 A polymorphism, the GG genotype had 1.78‐fold increased risk of prostate cancer compared with the AA genotype. However, no association was found regarding G leason score, advanced and metastatic prostate cancer risk.Conclusions It seems that there is no association of prostate cancer with MnSOD Ile58Thr polymorphism, whereas the TT genotype in the CAT C ‐262 T polymorphism and the GG genotype in the MPO G ‐463 A polymorphism may be associated with increased prostate cancer risk. The TT genotype in the CAT C ‐262 T gene polymorphism may also be a risk factor in tumour progression and metastasis among T urkish men.