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Severity of hydronephrosis correlates with tumour invasiveness and urinary bladder recurrence of ureteric cancer
Author(s) -
Luo Hao Lun,
Kang Chih Hsiung,
Chen Yen Ta,
Chuang Yao Chi,
Lee Wei Ching,
Cheng Yuan Tso,
Chiang Po Hui
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/bju.12157
Subject(s) - hydronephrosis , medicine , bladder cancer , pathological , urology , univariate analysis , urinary system , proportional hazards model , cancer , urinary bladder , multivariate analysis
Objectives To explore the prognostic role of hydronephrosis grade in patients with pure ureteric cancer.Patients and Methods The study included 162 patients with pure ureteric cancer who were treated between J anuary 2005 and D ecember 2010 at a single tertiary referral centre. The association between hydronephrosis grade with pathological findings and oncological outcomes was assessed using multivariate C ox regression analysis.Results Hydronephrosis grade >2 was independently associated with non‐organ‐confined ureteric cancer ( P = 0.003). Hydronephrosis grade <2 was highly prevalent in organ‐confined disease. Hydronephrosis grade >2 and bladder cancer history independently predict bladder cancer recurrence ( P = 0.021 and P = 0.002, respectively) Hydronephrosis of grade >2 was found to be associated with local and distant recurrence only in univariate analysis; non‐organ‐confined pathology independently predicted local and distant oncological failure ( P ≤ 0.001 and P = 0.002, respectively).Conclusions Hydronephrosis grade >2 is associated with non‐organ‐confined ureteric cancer and with bladder cancer recurrence. Non‐organ‐confined pathology is still the most important predictor for local and distant oncological failure.