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Clinically distinct trajectories of fatigue and their longitudinal relationship with the disturbance of personal goals following a cancer diagnosis
Author(s) -
Müller Fabiola,
Tuinman Marrit A.,
Janse Moniek,
Almansa Josué,
Sprangers Mirjam A. G.,
Smink Ans,
Ranchor Adelita V.,
Fleer Joke,
Hagedoorn Mariët
Publication year - 2017
Publication title -
british journal of health psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 88
eISSN - 2044-8287
pISSN - 1359-107X
DOI - 10.1111/bjhp.12253
Subject(s) - disturbance (geology) , medicine , cancer related fatigue , longitudinal study , cancer , prospective cohort study , physical therapy , pathology , paleontology , biology
Objectives Most studies on fatigue in patients with cancer aggregate its prevalence and severity on a group level, ignoring the possibility that subgroups of patients may differ widely in their development of fatigue. This study aimed to identify subgroups of patients with clinically distinct trajectories of fatigue from diagnosis to 18 months post‐diagnosis. As fatigue might trigger goal disturbance, the study also identified trajectories of concrete and abstract goal disturbance and longitudinally examined their co‐occurrence with fatigue. Design Prospective design with quantitative and qualitative method of data collection. Methods Patients with colorectal cancer ( n = 183) reported on their levels of fatigue and goal disturbance shortly after diagnosis ( T 1 ) and at 7 months ( T 2 ) and 18 months ( T 3 ) post‐diagnosis. Growth mixture model analyses were performed to identify trajectories of fatigue and goal disturbance. Guidelines for the clinical relevance of fatigue were applied. Results Four clinically distinct trajectories of fatigue were identified as follows: (1) persistent severe fatigue (25.4%), (2) moderate fatigue (56.1%), (3) no fatigue (13.8%), and (4) rapidly improving fatigue (4.7%). The majority of patients with cancer reported high disturbance of their concrete goals, while high disturbance of abstract goals was less evident. Fatigue and concrete goal disturbance co‐occurred longitudinally. Conclusions The fatigue and goal disturbance experienced from diagnosis to 18 months post‐diagnosis differ considerably for subgroups of patients with cancer. Fatigue and concrete goal disturbance are persistent burdens in the majority of patients. Investigating symptom burden beyond average trends can guide clinicians to identify patients most in need for treatment. Targeting goal disturbance might benefit the psychological well‐being in patients suffering from persistent symptoms.Statement of contribution What is already known on this subject?Fatigue is a common and distressing symptom at all stages of the cancer experience. Earlier studies suggest that many patients recover from fatigue after treatment completion. Patients with cancer experience disturbance in their personal goals, which is related to poor psychological well‐being.What does this study add?Developments of fatigue and goal disturbance differ between subgroups of patients with cancer but co‐occur within these subgroups. About 30% of the patients experience severe fatigue after diagnosis, of which only few patients recover within 18 months post‐diagnosis. Targeting goal disturbance might benefit patients with severe and ongoing symptoms.