Premium
A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia ( ALL ) in the Nordic and Baltic countries: Different practices of assessment and management
Author(s) -
Andersson Nadine G.,
Rathe Mathias,
Mølle Ingolf,
Jarvis Kirsten Brunswig,
Hoffmann Marianne,
Huurre Anu,
Joelsson Joel,
Albertsen Birgitte Klug,
Lohi Olli,
Långström Satu,
Overgaard Ulrik,
Saulyte Trakymiene Sonata,
Vepsäläinen Kaisa,
Vogt Hartmut,
Ranta Susanna
Publication year - 2022
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.18397
Subject(s) - medicine , coagulation , pediatrics , intensive care medicine
Summary Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low‐molecular‐weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.