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Third dose of COVID‐19 vaccine restores immune response in patients with haematological malignancies after loss of protective antibody titres
Author(s) -
Šušol Ondrej,
Hájková Barbora,
Zelená Hana,
Hájek Roman
Publication year - 2022
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.18073
Subject(s) - medicine , seroconversion , antibody , immunology , immune system , covid-19 , antibody response , antibody therapy , virology , monoclonal antibody , outbreak , disease , infectious disease (medical specialty)
Summary We have vaccinated 392 patients with two doses of mRNA COMIRNATY vaccine with an overall antibody response of 70% (best in cMPN, worst in CLL). We have then vaccinated 80 patients who did not achieve seroconversion or were low responders with a third dose of COMIRNATY vaccine. Our first results show promise, especially for patients on anti‐CD38 therapy.