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Infant T‐cell acute lymphoblastic leukaemia with t(6;7) ( TCRB‐MYB ) translocation
Author(s) -
Ramdeny Pemantah Sandheeah,
Mullanfroze Khushnuma,
Lorenzo Paola,
Grazia Valsecchi Maria,
Meijerink Jules,
Pieters Rob,
Baruchel Andre,
Vora Ajay
Publication year - 2021
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.17609
Subject(s) - medicine , t cell , disease , chromosomal translocation , immunology , biology , immune system , gene , genetics
Summary T‐ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant‐06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T‐cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.
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